再生医療

再生医療

細胞シートによる食道狭窄治療

　当院で、食道狭窄治療における細胞シートを使った自由診療の再生医療が始まります。
　細胞シート工学は、再生医療を飛躍的に進歩させる画期的な技術として注目されています。

治療の流れ

①治療説明、各種検査

　消化器外科にて、治療についてご説明します。問診、血液検査、既往症等の確認、術前検査などから治療への適格性を確認します。医師が必要と認める場合は、内視鏡検査を実施する場合もあります。

②口腔粘膜組織、自己血清の採取

　口腔外科にて、細胞シートを作るために、口腔粘膜組織を2～4㎠程度、血液を150～200ml採取します。食道と同じ扁平上皮という組織でつながっている、口腔粘膜の細胞を利用します。口腔外科での採取では入院の必要はありません。
　採取した組織と血液は細胞培養センターへ運搬し、約3週間を経て患者さんの細胞シートを製造します。

③細胞シート移植手術

　細胞シートを移植します。（1枚あたり10分程度圧迫し⽣着。平均7〜8枚使⽤）入院期間はおよそ8日間予定です。

対象の患者さん

・表在性食道がんの治療としてESDを予定しており、術後食道狭窄の可能性が高い方
・既にＥＳＤ後の難治性食道狭窄の症状を抱えている方

治療費の目安

本治療は自費診療となります。
保険診療による治療を進める過程の中で、細胞シートの使用が決定した場合、 初診に遡って自費となります。
※口腔粘膜培養食道細胞シート費用：3,325,000円

ESD＋細胞シート移植、入院期間８日間とした場合

Regenerative Medicine

Esophageal Stricture Treatment Using Regenerative Cell Sheet Therapy

Available Only at Tokyo Metropolitan Tama-Hokubu Medical Center
We are proud to offer an innovative regenerative therapy for esophageal strictures using cultured epithelial cell sheets, now available as a private (non-insurance covered) medical treatment for international patients.

This treatment is especially beneficial for patients who are at high risk of developing esophageal strictures after undergoing endoscopic submucosal dissection (ESD) for early-stage esophageal cancer, as well as for those who already suffer from severe post-ESD esophageal narrowing.

This advanced therapy is currently only available at our hospital.

What Is Cell Sheet Engineering?

Cell sheet engineering is a cutting-edge regenerative medicine technique that enables the transplantation of intact layers of cells. Using this approach, we culture epithelial cell sheets derived from the patient’s own oral mucosa. These sheets are then transplanted to the esophagus to promote healing and prevent or treat strictures without the need for synthetic scaffolds or extensive surgery.

Treatment Process

1. Initial Consultation and Screening

- Visit to the Department of Gastroenterological Surgery
- Explanation of the treatment process
- Medical history review, blood tests, preoperative assessments
- Endoscopy, if deemed necessary

2. Collection of Oral Mucosa and Autologous Serum

- Performed by the Department of Oral Surgery
- Harvesting 2–4 cm² of oral mucosal tissue and 150–200 ml of blood
- No hospitalization required
- Transport of samples to a certified cell processing facility
- Cell sheet preparation takes approximately three weeks

3. Cell Sheet Transplantation

- Endoscopic transplantation of cell sheets
- Each sheet is applied and held for about 10 minutes
- Average of 7–8 sheets used
- Hospitalization required for approximately 8 days

Eligible Patients

- Patients scheduled for ESD who are at high risk of post-ESD strictures
- Patients suffering from refractory strictures after ESD

Estimated Costs (Private Treatment)

Note: Once cell sheet therapy is selected as part of your treatment, the entire process will be considered a self-funded medical service from the initial visit. Documentation for visa purposes and cost estimates can be provided upon request.

Contact and Consultation

Tokyo Metropolitan Tama-Hokubu Medical Center
Department of Gastroenterological Surgery
1-7-1 Aoba-cho, Higashimurayama-shi, Tokyo 189-8511, Japan
Phone: +81-42-396-3811 (main)
Email: [insert international patient contact email]